An A-ring substituted evodiamine derivative with potent anticancer activity against human non-small cell lung cancer cells by targeting heat shock protein 70.

Min, Hye-Young; Lim, Yijae; Kwon, Hyukjin; Boo, Hye-Jin; Yeob Hyun, Seung; Hong, Junhwa; Hong, Suckchang; Lee, Ho-Young

Min, Hye-Young; Lim, Yijae; Kwon, Hyukjin; Boo, Hye-Jin; Yeob Hyun, Seung; Hong, Junhwa; Hong, Suckchang; Lee, Ho-Young.

Afiliação

Min HY; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea.
Lim Y; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea.
Kwon H; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea.
Boo HJ; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea.
Yeob Hyun S; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea.
Hong J; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea.
Hong S; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea.
Lee HY; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea. Electronic address: hylee135@snu.ac.kr.

Biochem Pharmacol ; 211: 115507, 2023 05.

Article em En | MEDLINE | ID: mdl-36958677

Assuntos

Antineoplásicos; Carcinoma Pulmonar de Células não Pequenas; Neoplasias Pulmonares; Humanos; Carcinoma Pulmonar de Células não Pequenas/metabolismo; Neoplasias Pulmonares/metabolismo; Proteínas de Choque Térmico HSP70/metabolismo; Linhagem Celular Tumoral; Proliferação de Células; Antineoplásicos/farmacologia; Antineoplásicos/uso terapêutico; Apoptose; Proteínas de Choque Térmico

Palavras-chave

Antitumor; Evodiamine; Heat shock protein 70; Non-small cell lung cancer

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Neoplasias Pulmonares / Antineoplásicos Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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