Structural Insights into Three Sesquiterpene Synthases for the Biosynthesis of Tricyclic Sesquiterpenes and Chemical Space Expansion by Structure-Based Mutagenesis.

Lou, Tingting; Li, Annan; Xu, Houchao; Pan, Jingfeng; Xing, Baiying; Wu, Ruibo; Dickschat, Jeroen S; Yang, Donghui; Ma, Ming

Lou, Tingting; Li, Annan; Xu, Houchao; Pan, Jingfeng; Xing, Baiying; Wu, Ruibo; Dickschat, Jeroen S; Yang, Donghui; Ma, Ming.

Afiliação

Lou T; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Haidian District, Beijing 100191, China.
Li A; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Haidian District, Beijing 100191, China.
Xu H; Kekulé-Institute for Organic Chemistry and Biochemistry, University of Bonn, Gerhard-Domagk-Strasse 1, 53121 Bonn, Germany.
Pan J; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Xing B; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Haidian District, Beijing 100191, China.
Wu R; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Dickschat JS; Kekulé-Institute for Organic Chemistry and Biochemistry, University of Bonn, Gerhard-Domagk-Strasse 1, 53121 Bonn, Germany.
Yang D; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Haidian District, Beijing 100191, China.
Ma M; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Haidian District, Beijing 100191, China.

J Am Chem Soc ; 2023 Apr 05.

Article em En | MEDLINE | ID: mdl-37018048

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

Texto completo

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China