Protection of melatonin treatment and combination with traditional antibiotics against septic myocardial injury.
Cell Mol Biol Lett
; 28(1): 35, 2023 Apr 26.
Article
em En
| MEDLINE
| ID: mdl-37101253
ABSTRACT
BACKGROUND:
Heart failure is a common complication of sepsis with a high mortality rate. It has been reported that melatonin can attenuate septic injury due to various properties. On the basis of previous reports, this study will further explore the effects and mechanisms of melatonin pretreatment, posttreatment, and combination with antibiotics in the treatment of sepsis and septic myocardial injury. METHODS ANDRESULTS:
Our results showed that melatonin pretreatment showed an obvious protective effect on sepsis and septic myocardial injury, which was related to the attenuation of inflammation and oxidative stress, the improvement of mitochondrial function, the regulation of endoplasmic reticulum stress (ERS), and the activation of the AMPK signaling pathway. In particular, AMPK serves as a key effector for melatonin-initiated myocardial benefits. In addition, melatonin posttreatment also had a certain degree of protection, while its effect was not as remarkable as that of pretreatment. The combination of melatonin and classical antibiotics had a slight but limited effect. RNA-seq detection clarified the cardioprotective mechanism of melatonin.CONCLUSION:
Altogether, this study provides a theoretical basis for the application strategy and combination of melatonin in septic myocardial injury.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sepse
/
Melatonina
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
China