THEMIS increases TCR signaling in CD4<sup>+</sup>CD8<sup>+</sup> thymocytes by inhibiting the activity of the tyrosine phosphatase SHP1.

Choi, Seeyoung; Lee, Jan; Hatzihristidis, Teri; Gaud, Guillaume; Dutta, Avik; Arya, Awadhesh; Clubb, Lauren M; Stamos, Daniel B; Markovics, Adrienn; Mikecz, Katalin; Love, Paul E

THEMIS increases TCR signaling in CD4⁺CD8⁺ thymocytes by inhibiting the activity of the tyrosine phosphatase SHP1.

Choi, Seeyoung; Lee, Jan; Hatzihristidis, Teri; Gaud, Guillaume; Dutta, Avik; Arya, Awadhesh; Clubb, Lauren M; Stamos, Daniel B; Markovics, Adrienn; Mikecz, Katalin; Love, Paul E.

Afiliação

Choi S; Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Lee J; Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Hatzihristidis T; Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Gaud G; Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Dutta A; Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Arya A; Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Clubb LM; Shock, Trauma and Anesthesiology Research (STAR) Center, University of Maryland, School of Medicine, Baltimore, MD 21201, USA.
Stamos DB; Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Markovics A; Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Mikecz K; Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA.
Love PE; Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA.

Sci Signal ; 16(784): eade1274, 2023 05 09.

Article em En | MEDLINE | ID: mdl-37159521

Assuntos

Peptídeos e Proteínas de Sinalização Intercelular; Proteína Tirosina Fosfatase não Receptora Tipo 6; Timócitos; Linfócitos T CD8-Positivos; Proteína Tirosina Fosfatase não Receptora Tipo 6/genética; Animais; Peptídeos e Proteínas de Sinalização Intercelular/genética

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos e Proteínas de Sinalização Intercelular / Proteína Tirosina Fosfatase não Receptora Tipo 6 / Timócitos Idioma: En Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

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