E3 Ubiquitin Ligases in Endothelial Dysfunction and Vascular Diseases: Roles and Potential Therapies.
J Cardiovasc Pharmacol
; 82(2): 93-103, 2023 08 01.
Article
em En
| MEDLINE
| ID: mdl-37314134
ABSTRACT
ABSTRACT Ubiquitin E3 ligases are a structurally conserved family of enzymes that exert a variety of regulatory functions in immunity, cell death, and tumorigenesis through the ubiquitination of target proteins. Emerging evidence has shown that E3 ubiquitin ligases play crucial roles in the pathogenesis of endothelial dysfunction and related vascular diseases. Here, we reviewed the new findings of E3 ubiquitin ligases in regulating endothelial dysfunction, including endothelial junctions and vascular integrity, endothelial activation, and endothelial apoptosis. The critical role and potential mechanism of E3 ubiquitin ligases in vascular diseases, such as atherosclerosis, diabetes, hypertension, pulmonary hypertension, and acute lung injury, were summarized. Finally, the clinical significance and potential therapeutic strategies associated with the regulation of E3 ubiquitin ligases were also proposed.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doenças Vasculares
/
Ubiquitina-Proteína Ligases
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
China