Silver/chiral pyrrolidinopyridine relay catalytic cycloisomerization/(2 + 3) cycloadditions of enynamides to asymmetrically synthesize bispirocyclopentenes as PDE1B inhibitors.

Jiang, Jing; Zhou, Jin; Li, Yang; Peng, Cheng; He, Gu; Huang, Wei; Zhan, Gu; Han, Bo

Jiang, Jing; Zhou, Jin; Li, Yang; Peng, Cheng; He, Gu; Huang, Wei; Zhan, Gu; Han, Bo.

Afiliação

Jiang J; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 611137, P.R. China.
Zhou J; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 611137, P.R. China.
Li Y; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 611137, P.R. China.
Peng C; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 611137, P.R. China.
He G; State Key Laboratory of Biotherapy and Department of Pharmacy, West China Hospital Sichuan University, Chengdu, 610041, P.R. China.
Huang W; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 611137, P.R. China.
Zhan G; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 611137, P.R. China. zhangu@cdutcm.edu.cn.
Han B; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 611137, P.R. China. hanbo@cdutcm.edu.cn.

Commun Chem ; 6(1): 128, 2023 Jun 19.

Article em En | MEDLINE | ID: mdl-37337043

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article