Bone Marrow Mesenchymal Stem Cell-Derived Extracellular Vesicle Infusion for the Treatment of Respiratory Failure From COVID-19: A Randomized, Placebo-Controlled Dosing Clinical Trial.

Lightner, Amy L; Sengupta, Vikram; Qian, Sascha; Ransom, John T; Suzuki, Sam; Park, David J; Melson, Timothy I; Williams, Brian P; Walsh, James J; Awili, Mustafa

Lightner, Amy L; Sengupta, Vikram; Qian, Sascha; Ransom, John T; Suzuki, Sam; Park, David J; Melson, Timothy I; Williams, Brian P; Walsh, James J; Awili, Mustafa.

Afiliação

Lightner AL; Direct Biologics, LLC, Austin, TX. Electronic address: ALightner@directbiologics.com.
Sengupta V; Direct Biologics, LLC, Austin, TX.
Qian S; Direct Biologics, LLC, Austin, TX.
Ransom JT; Direct Biologics, LLC, Austin, TX.
Suzuki S; Direct Biologics, LLC, Austin, TX.
Park DJ; Providence St Jude Medical Center/Providence Medical Foundation, Fullerton, CA.
Melson TI; Helen Keller Hospital, Sheffield, AL.
Williams BP; Covenant Health, Lubbock, TX.
Walsh JJ; Donald Guthrie Foundation, Sayre, PA.
Awili M; PRX Research, Mesquite, TX.

Chest ; 164(6): 1444-1453, 2023 12.

Article em En | MEDLINE | ID: mdl-37356708

Assuntos

COVID-19; Vesículas Extracelulares; Células-Tronco Mesenquimais; Síndrome do Desconforto Respiratório; Insuficiência Respiratória; Humanos; COVID-19/complicações; COVID-19/terapia; Estudos Prospectivos; Resultado do Tratamento; Síndrome do Desconforto Respiratório/terapia; Método Duplo-Cego

Palavras-chave

COVID-19; bone marrow mesenchymal stem cell; efficacy; extracellular vesicle; safety

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Síndrome do Desconforto Respiratório / Insuficiência Respiratória / Células-Tronco Mesenquimais / Vesículas Extracelulares / COVID-19 Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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