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MOV10 recruits DCP2 to decap human LINE-1 RNA by forming large cytoplasmic granules with phase separation properties.
Liu, Qian; Yi, Dongrong; Ding, Jiwei; Mao, Yang; Wang, Shujie; Ma, Ling; Li, Quanjie; Wang, Jing; Zhang, Yongxin; Zhao, Jianyuan; Guo, Saisai; Liu, Zhenlong; Guo, Fei; Zhao, Dongbing; Liang, Chen; Li, Xiaoyu; Peng, Xiaozhong; Cen, Shan.
Afiliação
  • Liu Q; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical School, Beijing, China.
  • Yi D; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical School, Beijing, China.
  • Ding J; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical School, Beijing, China.
  • Mao Y; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical School, Beijing, China.
  • Wang S; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical School, Beijing, China.
  • Ma L; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical School, Beijing, China.
  • Li Q; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical School, Beijing, China.
  • Wang J; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical School, Beijing, China.
  • Zhang Y; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical School, Beijing, China.
  • Zhao J; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical School, Beijing, China.
  • Guo S; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical School, Beijing, China.
  • Liu Z; Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, QC, Canada.
  • Guo F; Institute of Pathogen Biology, Chinese Academy of Medical Science, Beijing, China.
  • Zhao D; National Cancer Center, Chinese Academy of Medical Sciences and Peking Union Medical School, Beijing, China.
  • Liang C; Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, QC, Canada.
  • Li X; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical School, Beijing, China.
  • Peng X; State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Medical Primate Research Center, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China.
  • Cen S; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical School, Beijing, China.
EMBO Rep ; 24(9): e56512, 2023 09 06.
Article em En | MEDLINE | ID: mdl-37437058
Long interspersed element 1 (LINE-1) is the only active autonomous mobile element in the human genome. Its transposition can exert deleterious effects on the structure and function of the host genome and cause sporadic genetic diseases. Tight control of LINE-1 mobilization by the host is crucial for genetic stability. In this study, we report that MOV10 recruits the main decapping enzyme DCP2 to LINE-1 RNA and forms a complex of MOV10, DCP2, and LINE-1 RNP, exhibiting liquid-liquid phase separation (LLPS) properties. DCP2 cooperates with MOV10 to decap LINE-1 RNA, which causes degradation of LINE-1 RNA and thus reduces LINE-1 retrotransposition. We here identify DCP2 as one of the key effector proteins determining LINE-1 replication, and elucidate an LLPS mechanism that facilitates the anti-LINE-1 action of MOV10 and DCP2.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: RNA Helicases / Grânulos Citoplasmáticos Idioma: En Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: RNA Helicases / Grânulos Citoplasmáticos Idioma: En Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China