Mathematical modeling indicates that regulatory inhibition of CD8+ T cell cytotoxicity can limit efficacy of IL-15 immunotherapy in cases of high pre-treatment SIV viral load.

Cody, Jonathan W; Ellis-Connell, Amy L; O'Connor, Shelby L; Pienaar, Elsje

Cody, Jonathan W; Ellis-Connell, Amy L; O'Connor, Shelby L; Pienaar, Elsje.

Afiliação

Cody JW; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, United States of America.
Ellis-Connell AL; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
O'Connor SL; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Pienaar E; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, United States of America.

PLoS Comput Biol ; 19(8): e1011425, 2023 08.

Article em En | MEDLINE | ID: mdl-37616311

Assuntos

Vírus da Imunodeficiência Símia; Animais; Interleucina-15; Carga Viral; Imunoterapia; Linfócitos T CD8-Positivos

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vírus da Imunodeficiência Símia Idioma: En Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

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