FunTaxIS-lite: a simple and light solution to investigate protein functions in all living organisms.
Bioinformatics
; 39(9)2023 09 02.
Article
em En
| MEDLINE
| ID: mdl-37672040
ABSTRACT
MOTIVATION Defining the full domain of protein functions belonging to an organism is a complex challenge that is due to the huge heterogeneity of the taxonomy, where single or small groups of species can bear unique functional characteristics. FunTaxIS-lite provides a solution to this challenge by determining taxon-based constraints on Gene Ontology (GO) terms, which specify the functions that an organism can or cannot perform. The tool employs a set of rules to generate and spread the constraints across both the taxon hierarchy and the GO graph. RESULTS:
The taxon-based constraints produced by FunTaxIS-lite extend those provided by the Gene Ontology Consortium by an average of 300%. The implementation of these rules significantly reduces errors in function predictions made by automatic algorithms and can assist in correcting inconsistent protein annotations in databases. AVAILABILITY AND IMPLEMENTATION FunTaxIS-lite is available on https//www.medcomp.medicina.unipd.it/funtaxis-lite and from https//github.com/MedCompUnipd/FunTaxIS-lite.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Algoritmos
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Itália