Integrative analysis reveals that SLC38A1 promotes hepatocellular carcinoma development via PI3K/AKT/mTOR signaling via glutamine mediated energy metabolism.

Feng, Hua-Guo; Wu, Chuan-Xin; Zhong, Guo-Chao; Gong, Jian-Ping; Miao, Chun-Mu; Xiong, Bin

Feng, Hua-Guo; Wu, Chuan-Xin; Zhong, Guo-Chao; Gong, Jian-Ping; Miao, Chun-Mu; Xiong, Bin.

Afiliação

Feng HG; Department of Hepatobiliary Surgery, the Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, No. 74 Linjiang Road, Chongqing, China.
Wu CX; Department of Hepatobiliary Surgery, the Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, No. 74 Linjiang Road, Chongqing, China.
Zhong GC; Department of Hepatobiliary Surgery, the Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, No. 74 Linjiang Road, Chongqing, China.
Gong JP; Department of Hepatobiliary Surgery, the Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, No. 74 Linjiang Road, Chongqing, China.
Miao CM; Department of Hepatobiliary Surgery, the Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, No. 74 Linjiang Road, Chongqing, China.
Xiong B; Department of Hepatobiliary Surgery, the Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, No. 74 Linjiang Road, Chongqing, China. 304370@hospital.cqmu.edu.cn.

J Cancer Res Clin Oncol ; 149(17): 15879-15898, 2023 Nov.

Article em En | MEDLINE | ID: mdl-37673823

Assuntos

Carcinoma Hepatocelular; Neoplasias Hepáticas; Humanos; Carcinoma Hepatocelular/patologia; Proteínas Proto-Oncogênicas c-akt/metabolismo; Fosfatidilinositol 3-Quinases/genética; Fosfatidilinositol 3-Quinases/metabolismo; Glutamina/metabolismo; Neoplasias Hepáticas/patologia; Proliferação de Células/genética; Serina-Treonina Quinases TOR/genética; Serina-Treonina Quinases TOR/metabolismo; Metabolismo Energético; Linhagem Celular Tumoral; Sistema A de Transporte de Aminoácidos/metabolismo

Palavras-chave

Biomarker; Glutamine; Hepatocellular carcinoma; Metabolismrelated genes; PI3K/AKT/mTOR signaling; SLC38A1

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma Hepatocelular / Neoplasias Hepáticas Idioma: En Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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