Integrating serum metabolomics and network analysis to explore the antidepressant activity of crocin in rats with chronic unexpected mild stress-induced depression.

Luo, Yan; Zhong, Ziyan; Li, Huan; Wang, Le; Guo, Dongwei; Dong, Xuanqi; Liu, Jian; Xie, Mingxia; Wu, Mei; Xiang, Yun; Zhang, Xi; Meng, Pan

Integrating serum metabolomics and network analysis to explore the antidepressant activity of crocin in rats with chronic unexpected mild stress-induced depression.

Luo, Yan; Zhong, Ziyan; Li, Huan; Wang, Le; Guo, Dongwei; Dong, Xuanqi; Liu, Jian; Xie, Mingxia; Wu, Mei; Xiang, Yun; Zhang, Xi; Meng, Pan.

Afiliação

Luo Y; Science and Technology Innovation Center, Hunan University of Chinese Medicine, Changsha, Hunan, P.R. China.
Zhong Z; Science and Technology Innovation Center, Hunan University of Chinese Medicine, Changsha, Hunan, P.R. China.
Li H; Science and Technology Innovation Center, Hunan University of Chinese Medicine, Changsha, Hunan, P.R. China.
Wang L; Science and Technology Innovation Center, Hunan University of Chinese Medicine, Changsha, Hunan, P.R. China.
Guo D; The Second People's Hospital of Hunan Province, Changsha, Hunan, P.R. China.
Dong X; The Second People's Hospital of Hunan Province, Changsha, Hunan, P.R. China.
Liu J; First Affiliated Hospital, Hunan University of Chinese Medicine, Changsha, Hunan, P.R. China.
Xie M; Science and Technology Innovation Center, Hunan University of Chinese Medicine, Changsha, Hunan, P.R. China.
Wu M; Science and Technology Innovation Center, Hunan University of Chinese Medicine, Changsha, Hunan, P.R. China.
Xiang Y; Science and Technology Innovation Center, Hunan University of Chinese Medicine, Changsha, Hunan, P.R. China.
Zhang X; The Second People's Hospital of Hunan Province, Changsha, Hunan, P.R. China.
Meng P; Science and Technology Innovation Center, Hunan University of Chinese Medicine, Changsha, Hunan, P.R. China.

Pharm Biol ; 61(1): 1414-1430, 2023 Dec.

Article em En | MEDLINE | ID: mdl-37688460

Assuntos

Antidepressivos; Depressão; Masculino; Ratos; Animais; Depressão/tratamento farmacológico; Ratos Sprague-Dawley; Antidepressivos/farmacologia; Antidepressivos/uso terapêutico; Metabolômica

Palavras-chave

Traditional Chinese medicine; interaction network; metabolism; network pharmacology; untargeted metabolomics

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Depressão / Antidepressivos Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

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PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Depressão / Antidepressivos Idioma: En Ano de publicação: 2023 Tipo de documento: Article