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TNFα increases the degradation of pyruvate dehydrogenase kinase 4 by the Lon protease to support proinflammatory genes.
Boutagy, Nabil E; Fowler, Joseph W; Grabinska, Kariona A; Cardone, Rebecca; Sun, Qiushi; Vazquez, Kyla R; Whalen, Michael B; Zhu, Xiaolong; Chakraborty, Raja; Martin, Kathleen A; Simons, Michael; Romanoski, Casey E; Kibbey, Richard G; Sessa, William C.
Afiliação
  • Boutagy NE; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520.
  • Fowler JW; Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT 06520.
  • Grabinska KA; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520.
  • Cardone R; Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT 06520.
  • Sun Q; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520.
  • Vazquez KR; Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT 06520.
  • Whalen MB; Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520.
  • Zhu X; Department Cellular & Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520.
  • Chakraborty R; Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520.
  • Martin KA; Department Cellular & Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520.
  • Simons M; Department of Cellular & Molecular Medicine, Bioscience Research Laboratories, University of Arizona, College of Medicine, Tucson, AZ 85724.
  • Romanoski CE; Department of Cellular & Molecular Medicine, Bioscience Research Laboratories, University of Arizona, College of Medicine, Tucson, AZ 85724.
  • Kibbey RG; Department of Cardiology, Yale University School of Medicine, New Haven, CT 06520.
  • Sessa WC; Department of Cardiology, Yale University School of Medicine, New Haven, CT 06520.
Proc Natl Acad Sci U S A ; 120(38): e2218150120, 2023 09 19.
Article em En | MEDLINE | ID: mdl-37695914
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fator de Necrose Tumoral alfa / Protease La Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fator de Necrose Tumoral alfa / Protease La Idioma: En Ano de publicação: 2023 Tipo de documento: Article