Clinical impact of COVID-19 in patients with carbapenem-resistant Acinetobacter baumannii bacteraemia.
Epidemiol Infect
; 151: e180, 2023 10 10.
Article
em En
| MEDLINE
| ID: mdl-37814587
ABSTRACT
The aim of this study was to evaluate the impact of coronavirus disease 2019 (COVID-19) on treatment outcomes in critically ill patients with carbapenem-resistant Acinetobacter baumannii (CRAB) bloodstream infection (BSI). This single-centre, retrospective cohort study was conducted in a 1,048-bed university-affiliated tertiary hospital in the Republic of Korea from January 2021 to March 2022. The study participants included consecutive hospitalised adult patients (aged ≥18 years) in the intensive care unit with CRAB monomicrobial BSI. During the study period, a total of 70 patients were included in our study, and 24 (34.3%) were diagnosed with COVID-19. The 28-day mortality rate was 64.3%. In the multivariate Cox proportional hazard regression analysis, diagnosis of COVID-19 (hazard ratio (HR), 2.91; 95% confidence interval (CI) 1.45-5.87), neutropenia (HR, 2.76; 95% CI 1.04-7.29), Pitt bacteraemia score (per point; HR, 1.30; 95% CI 1.19-1.41), and appropriate definite antibiotic therapy (HR, 0.31; 95% CI 0.15-0.62) were independent predictors of 28-day mortality in patients with CRAB BSI. In conclusion, our findings suggested that COVID-19 has a negative prognostic impact on patients with CRAB BSI. Further study is needed to investigate the specific mechanisms of how COVID-19 worsens the prognosis of CRAB infection.
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Base de dados:
MEDLINE
Assunto principal:
Infecções por Acinetobacter
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Bacteriemia
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Acinetobacter baumannii
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COVID-19
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article