Multifunctional effects of Lactobacillus sakei HEM 224 on the gastrointestinal tract and airway inflammation.
Sci Rep
; 13(1): 17918, 2023 10 20.
Article
em En
| MEDLINE
| ID: mdl-37864021
ABSTRACT
Mucosal tissues serve as the first defense line and their commensal microbiota play a role in sustaining of host health. This study aimed to isolate and evaluate a putative probiotic strain on various mucosal regions. Lactobacillus sakei HEM 224 was isolated from traditional Korean kimchi and identified. In the safety assessment L. sakei HEM 224 showed negative results for hemolysis, biogenic amine production and transferable antibiotic resistance. The probiotic potential of strain HEM 224 in diverse mucosal areas was shown in two different models, viz. a murine model with colitis induced by dextran sulfate sodium (DSS) and an allergic airway inflammation model induced by ovalbumin (OVA). In the colitis model, oral administration of L. sakei HEM 224 improved colitis physiology with immunomodulation, enhancing barrier components and gut microbiota alteration. In the allergic airway inflammation model, the intranasal administration of the strain decreased type 2 inflammation and enhanced epithelial barrier integrity from the airways. These results demonstrate that L. sakei HEM 224 can ameliorate inflammatory conditions in both the gastrointestinal and respiratory tracts through the reinforcement of the epithelial barrier and immunomodulation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Colite
/
Probióticos
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Latilactobacillus sakei
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article