T cell receptor sequences are the dominant factor contributing to the phenotype of CD8<sup>+</sup> T cells with specificities against immunogenic viral antigens.

Chen, Daniel G; Xie, Jingyi; Su, Yapeng; Heath, James R

T cell receptor sequences are the dominant factor contributing to the phenotype of CD8⁺ T cells with specificities against immunogenic viral antigens.

Chen, Daniel G; Xie, Jingyi; Su, Yapeng; Heath, James R.

Afiliação

Chen DG; Institute of Systems Biology, Seattle, WA 98109, USA; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Clinical Research Division, Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Xie J; Institute of Systems Biology, Seattle, WA 98109, USA; Molecular Engineering & Sciences Institute, University of Washington, Seattle, WA 98105, USA.
Su Y; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Clinical Research Division, Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Heath JR; Institute of Systems Biology, Seattle, WA 98109, USA; Department of Bioengineering, University of Washington, Seattle, WA 98105, USA. Electronic address: jim.heath@isbscience.org.

Cell Rep ; 42(11): 113279, 2023 11 28.

Article em En | MEDLINE | ID: mdl-37883974

Assuntos

Linfócitos T CD8-Positivos; COVID-19; Humanos; Antígenos Virais; Estudos Longitudinais; Receptores de Antígenos de Linfócitos T/metabolismo; Fenótipo

Palavras-chave

CD8(+) T cells; CP: Immunology; T cell receptor; single-cell multi-omics; systems immunology

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos T CD8-Positivos / COVID-19 Idioma: En Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

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