[Indicators of spontaneous behavior of rhesus monkeys with short-term course alcohol self-administration under free choice]. / Pokazateli spontannogo povedeniya makak-rezus pri subkhronicheskom potreblenii alkogolya v modeli so svobodnym vyborom.

ABSTRACT

OBJECTIVE: To analyze spontaneous behavior in 36 male rhesus macaques during formation of alcoholic motivation under free choice. MATERIAL AND METHODS: The model composed the initiation stage with the provision of an aqueous ethanol solution of increasing concentration from 1 to 4% with a sweetener and restricted access to the tap water supply and the subsequent stage of the formation of alcoholic motivation with a free choice between 4% ethanol solution without sweetener and water. The behavior was recorded by the «One-Zero¼ method with ethogram compiled in accordance with the behavioral peculiarities of rhesus monkeys when housed individually. Three subgroups of high, medium and low-level ethanol consumption were distinguished. RESULTS: In the subgroup of high ethanol consumption median consumption was 1.70 g/kg/day at initiation (p<0.05, compared to other subgroups) and 1.79 g/kg/day (p<0.05) at free choice stage. Animals of high consumption subgroup had significantly higher frequency being at the cage bottom and in a sitting posture. We observed significant changes in a number of indicators of spontaneous behavior depending on the level of ethanol consumption, which included displacement behavior, stereotypic behavior and posture of animals. In the high consumption subgroup, there was a significant increase in the frequency of stereotypic behavior, atypical behavior, being on four legs, as well as a decrease in the frequency of being at the back side of the cage and of displacement behavior. At the same time, the inhibitory effect of ethanol on the hypothalamic-pituitary-adrenal system was revealed. CONCLUSION: In the model of free choice alcohol self-administration rhesus monkeys demonstrate a significant change in a number of indicators of spontaneous behavior depending on the level of ethanol consumption, which includes displacement, stereotypic behaviors and animal posture.