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A road map for the treatment of pediatric diffuse midline glioma.
Koschmann, Carl; Al-Holou, Wajd N; Alonso, Marta M; Anastas, Jamie; Bandopadhayay, Pratiti; Barron, Tara; Becher, Oren; Cartaxo, Rodrigo; Castro, Maria G; Chung, Chan; Clausen, Madison; Dang, Derek; Doherty, Robert; Duchatel, Ryan; Dun, Matthew; Filbin, Mariella; Franson, Andrea; Galban, Stefanie; Garcia Moure, Marc; Garton, Hugh; Gowda, Pruthvi; Marques, Joana Graca; Hawkins, Cynthia; Heath, Allison; Hulleman, Esther; Ji, Sunjong; Jones, Chris; Kilburn, Lindsay; Kline, Cassie; Koldobskiy, Michael A; Lim, Daniel; Lowenstein, Pedro R; Lu, Q Richard; Lum, Joanna; Mack, Stephen; Magge, Suresh; Marini, Bernard; Martin, Donna; Marupudi, Neena; Messinger, Dana; Mody, Rajen; Morgan, Meredith; Mota, Mateus; Muraszko, Karin; Mueller, Sabine; Natarajan, Siva Kumar; Nazarian, Javad; Niculcea, Michael; Nuechterlein, Nicholas; Okada, Hideho.
Afiliação
  • Koschmann C; University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: ckoschma@med.umich.edu.
  • Al-Holou WN; University of Michigan, Ann Arbor, MI 48109, USA.
  • Alonso MM; Clinica Universidad de Navarra, Navarra, Spain.
  • Anastas J; Baylor College of Medicine, Houston, TX 77030, USA.
  • Bandopadhayay P; Dana-Faber Cancer Institute, Boston, MA 02215, USA.
  • Barron T; Stanford University, Stanford, CA 94305, USA.
  • Becher O; Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Cartaxo R; University of Michigan, Ann Arbor, MI 48109, USA.
  • Castro MG; University of Michigan, Ann Arbor, MI 48109, USA.
  • Chung C; Daegu Gyeongbuk Institute of Science & Technology, Daegu, South Korea.
  • Clausen M; University of Michigan, Ann Arbor, MI 48109, USA.
  • Dang D; University of Michigan, Ann Arbor, MI 48109, USA.
  • Doherty R; University of Michigan, Ann Arbor, MI 48109, USA.
  • Duchatel R; University of Newcastle, Callaghan, NSW 2308, Australia.
  • Dun M; University of Newcastle, Callaghan, NSW 2308, Australia.
  • Filbin M; Dana-Faber Cancer Institute, Boston, MA 02215, USA.
  • Franson A; University of Michigan, Ann Arbor, MI 48109, USA.
  • Galban S; University of Michigan, Ann Arbor, MI 48109, USA.
  • Garcia Moure M; Clinica Universidad de Navarra, Navarra, Spain.
  • Garton H; University of Michigan, Ann Arbor, MI 48109, USA.
  • Gowda P; Dana-Faber Cancer Institute, Boston, MA 02215, USA.
  • Marques JG; Clinica Universidad de Navarra, Navarra, Spain.
  • Hawkins C; Hospital for Sick Children, Toronto, ON M5G 1E8, Canada.
  • Heath A; Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
  • Hulleman E; Princess Maxima Center, 3584 CS Utrecht, the Netherlands.
  • Ji S; University of Michigan, Ann Arbor, MI 48109, USA.
  • Jones C; Division of Molecular Pathology, Institute for Cancer Research, London SM2 5NG, UK.
  • Kilburn L; Children's National, Washington, DC 20010, USA.
  • Kline C; Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
  • Koldobskiy MA; John Hopkins University, Baltimore, MD 21205, USA.
  • Lim D; University of California, San Francisco, San Francisco, CA 94143, USA.
  • Lowenstein PR; University of Michigan, Ann Arbor, MI 48109, USA.
  • Lu QR; Cincinnati Children's Hospital Medical Center, and University of Cincinnati, Cincinnati, OH 45229, USA.
  • Lum J; University of Michigan, Ann Arbor, MI 48109, USA.
  • Mack S; St. Jude, Memphis, TN 38105, USA.
  • Magge S; University of Michigan, Ann Arbor, MI 48109, USA.
  • Marini B; University of Michigan, Ann Arbor, MI 48109, USA.
  • Martin D; University of Michigan, Ann Arbor, MI 48109, USA.
  • Marupudi N; University of Michigan, Ann Arbor, MI 48109, USA.
  • Messinger D; University of Michigan, Ann Arbor, MI 48109, USA.
  • Mody R; University of Michigan, Ann Arbor, MI 48109, USA.
  • Morgan M; University of Michigan, Ann Arbor, MI 48109, USA.
  • Mota M; University of Michigan, Ann Arbor, MI 48109, USA.
  • Muraszko K; University of Michigan, Ann Arbor, MI 48109, USA.
  • Mueller S; University of California, San Francisco, San Francisco, CA 94143, USA; Parker Institute for Cancer Immunotherapy, University of Zurich, Zurich, Switzerland.
  • Natarajan SK; University of Michigan, Ann Arbor, MI 48109, USA.
  • Nazarian J; Children's National, Washington, DC 20010, USA; University of Zurich, Zurich, Switzerland.
  • Niculcea M; University of Michigan, Ann Arbor, MI 48109, USA.
  • Nuechterlein N; University of Michigan, Ann Arbor, MI 48109, USA; National Institutes of Health, Bethesda, MD, USA.
  • Okada H; University of California, San Francisco, San Francisco, CA 94143, USA.
Cancer Cell ; 42(1): 1-5, 2024 01 08.
Article em En | MEDLINE | ID: mdl-38039965
ABSTRACT
Recent clinical trials for H3K27-altered diffuse midline gliomas (DMGs) have shown much promise. We present a consensus roadmap and identify three major barriers (1) refinement of experimental models to include immune and brain-specific components; (2) collaboration among researchers, clinicians, and industry to integrate patient-derived data through sharing, transparency, and regulatory considerations; and (3) streamlining clinical efforts including biopsy, CNS-drug delivery, endpoint determination, and response monitoring. We highlight the importance of comprehensive collaboration to advance the understanding, diagnostics, and therapeutics for DMGs.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Glioma Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Glioma Idioma: En Ano de publicação: 2024 Tipo de documento: Article