Polarized Th2 cells attenuate high-fat-diet induced obesity through the suppression of lipogenesis.
BMC Immunol
; 25(1): 4, 2024 01 10.
Article
em En
| MEDLINE
| ID: mdl-38195424
ABSTRACT
Immune cells, such as macrophages, B cells, neutrophils and T cell subsets, have been implicated in the context of obesity. However, the specific role of Th2 cells in adipose tissue function has remained elusive. Eight-week-old male CD3εâ/â mice were randomly divided into two groups (≥ 5 mice per group) one received intravenous injection of Th2 cells isolated from LATY136F mice, while the other receiving PBS as a control. Both of groups were subjected to a high-fat diet (HFD). The adoptive transfer of polarized Th2 cells led to a significant reduction in obesity following a HFD. This reduction was accompanied by improvements in hepatic steatosis, glucose intolerance, and insulin resistance. Mechanistically, Th2 cell treatment promoted oxidative phosphorylation of adipocytes, thereby contributing to a reduction of lipid droplet accumulation. These findings suggest that Th2 cell therapy represents a novel approach for treating diet-induced obesity and other diseases involving lipid droplet accumulation disorders.
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Base de dados:
MEDLINE
Assunto principal:
Lipogênese
/
Dieta Hiperlipídica
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article