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A self-powered intracardiac pacemaker in swine model.
Liu, Zhuo; Hu, Yiran; Qu, Xuecheng; Liu, Ying; Cheng, Sijing; Zhang, Zhengmin; Shan, Yizhu; Luo, Ruizeng; Weng, Sixian; Li, Hui; Niu, Hongxia; Gu, Min; Yao, Yan; Shi, Bojing; Wang, Ningning; Hua, Wei; Li, Zhou; Wang, Zhong Lin.
Afiliação
  • Liu Z; Beijing Key Laboratory of Micro-nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, 101400, Beijing, China.
  • Hu Y; Key Laboratory of Biomechanics and Mechanobiology, Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Engineering Medicine, Beihang University, 100191, Beijing, China.
  • Qu X; Department of Cardiology, The Cardiac Arrhythmia Center, State Key Laboratory of Cardiovascular Disease, National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 10
  • Liu Y; Department of Cardiology and Macrovascular Disease, Beijing Tiantan Hospital, Capital Medical University, 100070, Beijing, China.
  • Cheng S; Beijing Key Laboratory of Micro-nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, 101400, Beijing, China.
  • Zhang Z; School of Nanoscience and Engineering, University of Chinese Academy of Sciences, 100049, Beijing, China.
  • Shan Y; Beijing Key Laboratory of Micro-nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, 101400, Beijing, China.
  • Luo R; School of Nanoscience and Engineering, University of Chinese Academy of Sciences, 100049, Beijing, China.
  • Weng S; Department of Cardiology, The Cardiac Arrhythmia Center, State Key Laboratory of Cardiovascular Disease, National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 10
  • Li H; School of Electronics and Information, Hangzhou Dianzi University, 310018, Hangzhou, China.
  • Niu H; Beijing Key Laboratory of Micro-nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, 101400, Beijing, China.
  • Gu M; Beijing Key Laboratory of Micro-nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, 101400, Beijing, China.
  • Yao Y; Department of Cardiology, The Cardiac Arrhythmia Center, State Key Laboratory of Cardiovascular Disease, National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 10
  • Shi B; Department of Ultrasound, State Key Laboratory of Cardiovascular Disease, National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 100037, Beijing, China.
  • Wang N; Department of Cardiology, The Cardiac Arrhythmia Center, State Key Laboratory of Cardiovascular Disease, National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 10
  • Hua W; Department of Cardiology, The Cardiac Arrhythmia Center, State Key Laboratory of Cardiovascular Disease, National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 10
  • Li Z; Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, 100029, Beijing, China.
  • Wang ZL; Beijing Key Laboratory of Micro-nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, 101400, Beijing, China.
Nat Commun ; 15(1): 507, 2024 Jan 13.
Article em En | MEDLINE | ID: mdl-38218947
ABSTRACT
Harvesting biomechanical energy from cardiac motion is an attractive power source for implantable bioelectronic devices. Here, we report a battery-free, transcatheter, self-powered intracardiac pacemaker based on the coupled effect of triboelectrification and electrostatic induction for the treatment of arrhythmia in large animal models. We show that the capsule-shaped device (1.75 g, 1.52 cc) can be integrated with a delivery catheter for implanting in the right ventricle of a swine through the intravenous route, which effectively converts cardiac motion energy to electricity and maintains endocardial pacing function during the three-week follow-up period. We measure in vivo open circuit voltage and short circuit current of the self-powered intracardiac pacemaker of about 6.0 V and 0.2 µA, respectively. This approach exhibits up-to-date progress in self-powered medical devices and it may overcome the inherent energy shortcomings of implantable pacemakers and other bioelectronic devices for therapy and sensing.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Marca-Passo Artificial Idioma: En Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Marca-Passo Artificial Idioma: En Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China