A self-powered intracardiac pacemaker in swine model.
Nat Commun
; 15(1): 507, 2024 Jan 13.
Article
em En
| MEDLINE
| ID: mdl-38218947
ABSTRACT
Harvesting biomechanical energy from cardiac motion is an attractive power source for implantable bioelectronic devices. Here, we report a battery-free, transcatheter, self-powered intracardiac pacemaker based on the coupled effect of triboelectrification and electrostatic induction for the treatment of arrhythmia in large animal models. We show that the capsule-shaped device (1.75 g, 1.52 cc) can be integrated with a delivery catheter for implanting in the right ventricle of a swine through the intravenous route, which effectively converts cardiac motion energy to electricity and maintains endocardial pacing function during the three-week follow-up period. We measure in vivo open circuit voltage and short circuit current of the self-powered intracardiac pacemaker of about 6.0 V and 0.2 µA, respectively. This approach exhibits up-to-date progress in self-powered medical devices and it may overcome the inherent energy shortcomings of implantable pacemakers and other bioelectronic devices for therapy and sensing.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Marca-Passo Artificial
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China