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Caged Xanthones and Biphenyls Isolated from the Tropical Plant Garcinia lateriflora.
Kobayashi, Ayano; Saito, Yohei; Miyake, Katsunori; Fukuyoshi, Shuichi; Newman, David J; O'Keefe, Barry R; Lee, Kuo-Hsiung; Nakagawa-Goto, Kyoko.
Afiliação
  • Kobayashi A; School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, 920-1192, Japan.
  • Saito Y; School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, 920-1192, Japan.
  • Miyake K; Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan.
  • Fukuyoshi S; School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, 920-1192, Japan.
  • Newman DJ; NIH Special Volunteer, Wayne, Pennsylvania 19087, United States.
  • O'Keefe BR; Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, NCI at Frederick, Frederick, Maryland 21702-1201, United States.
  • Lee KH; Molecular Targets Program, Center for Cancer Research, National Cancer Institute, NCI at Frederick, Frederick, Maryland 21702-1201, United States.
  • Nakagawa-Goto K; Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7568, United States.
J Nat Prod ; 87(2): 266-275, 2024 02 23.
Article em En | MEDLINE | ID: mdl-38251859
ABSTRACT
Four cytotoxic heptacyclic caged-xanthones [gambogefic acids B-E (1-4)], a cytotoxic hexacyclic caged-xanthone [garcilatelic acid (5)], and four biphenyl derivatives [garcilatelibiphenyls A-D (6-9)] were newly isolated in a phytochemical study of a 50% MeOH/CH2Cl2 extract of Garcinia lateriflora (Clusiaceae). The isolated compounds were evaluated for antiproliferative activity against five human tumor cell lines including a vincristine-resistant line. The new caged-xanthones displayed potent activity with IC50 values from 0.5 to 6.7 µM against all tested tumor cell lines.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Garcinia / Xantonas / Antineoplásicos Fitogênicos Idioma: En Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Japão
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Garcinia / Xantonas / Antineoplásicos Fitogênicos Idioma: En Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Japão