Caged Xanthones and Biphenyls Isolated from the Tropical Plant Garcinia lateriflora.
J Nat Prod
; 87(2): 266-275, 2024 02 23.
Article
em En
| MEDLINE
| ID: mdl-38251859
ABSTRACT
Four cytotoxic heptacyclic caged-xanthones [gambogefic acids B-E (1-4)], a cytotoxic hexacyclic caged-xanthone [garcilatelic acid (5)], and four biphenyl derivatives [garcilatelibiphenyls A-D (6-9)] were newly isolated in a phytochemical study of a 50% MeOH/CH2Cl2 extract of Garcinia lateriflora (Clusiaceae). The isolated compounds were evaluated for antiproliferative activity against five human tumor cell lines including a vincristine-resistant line. The new caged-xanthones displayed potent activity with IC50 values from 0.5 to 6.7 µM against all tested tumor cell lines.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Garcinia
/
Xantonas
/
Antineoplásicos Fitogênicos
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Japão