Incidence and risk factors for developing chemotherapy-induced neuropathic pain in 500 cancer patients: A file-based observational study.
J Peripher Nerv Syst
; 29(1): 38-46, 2024 Mar.
Article
em En
| MEDLINE
| ID: mdl-38311337
ABSTRACT
OBJECTIVE:
To define the incidence and risk factors for developing chemotherapy-induced neuropathic pain (CINP).METHODS:
Retrospective, file-based analysis on cancer patients who received any type of conventional chemotherapy and for whom neurological evaluation was asked to reveal the extent of chemotherapy-induced peripheral neurotoxicity (CIPN) with or without CINP. CINP was assessed by means of the PI-NRS and Douleur Neuropathique-4 questionnaire. The total neuropathy score-clinical version graded the severity of CIPN.RESULTS:
The medical files of 500 chemotherapy-treated cancer patients were reviewed. Any grade chronic CIPN was disclosed in 343 (68.6%) patients and CINP in 127 (37%) of them, corresponding to an overall percentage of 25.4% among all 500 included patients. The logistic regression analysis identified as independent predictors for CINP development the presence of uncomplicated diabetes (OR 2.17; p = .039) and grade 2-3 chronic CIPN (OR 1.61; p < .001) as also the administration of combined paclitaxel plus cisplatin (reference variable), compared to oxaliplatin (OR 0.18; p = .001) and taxanes (OR 0.16; p < .001). The increased severity of acute OXAIPN was associated with CINP (OR 4.51; p < .001). OXA-treated patients with persistent CINP presented a worst likelihood to improve after chemotherapy discontinuation, than patients receiving combined paclitaxel plus cisplatin (OR 50; p < .001).CONCLUSION:
The incidence of CINP in our cohort was comparable to previous reports, with severities fluctuating upwards during chemotherapy and declined post-chemotherapy. Uncomplicated diabetes, the combined paclitaxel plus cisplatin treatment and the increased severity of acute oxaliplatin neurotoxicity mostly increase the risk for developing CINP. OXA-treated patients present less possibilities to recover from CINP after chemotherapy discontinuation, than other chemotherapies.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Síndromes Neurotóxicas
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Diabetes Mellitus
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Neoplasias
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Neuralgia
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Antineoplásicos
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Grécia