Electrochemical Radical Retro-Allylation of Homoallylic Alcohols with Sulfonyl Hydrazides.
J Org Chem
; 89(5): 3563-3572, 2024 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-38335535
ABSTRACT
We report herein the first examples of electrochemical radical retro-allylation of homoallylic alcohols via the cleavage of the C(sp3)-C(sp3) bond. In this reaction, a variety of sulfonyl hydrazides were employed as the environmentally friendly radical sources via an electrochemical dehydrazination with the release of N2 and H2 as the byproducts, leading to sulfonyl allylic compounds in moderate to good yields. The reaction features metal- and base-free reaction conditions, broad functional group tolerance, and a broad substrate scope.
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MEDLINE
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En
Ano de publicação:
2024
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Article