Roles of RNA m6A modification in nonalcoholic fatty liver disease.

Tan, Jian; Wang, Yue-Fan; Dai, Zhi-Hui; Yin, Hao-Zan; Mu, Chen-Yang; Wang, Si-Jie; Yang, Fu

Tan, Jian; Wang, Yue-Fan; Dai, Zhi-Hui; Yin, Hao-Zan; Mu, Chen-Yang; Wang, Si-Jie; Yang, Fu.

Afiliação

Tan J; The Department of Medical Genetics, Naval Medical University, Shanghai, China.
Wang YF; The Department of Medical Genetics, Naval Medical University, Shanghai, China.
Dai ZH; The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital Affiliated to Naval Medical University, Shanghai, China.
Yin HZ; The Department of Medical Genetics, Naval Medical University, Shanghai, China.
Mu CY; The Department of Medical Genetics, Naval Medical University, Shanghai, China.
Wang SJ; The Department of Medical Genetics, Naval Medical University, Shanghai, China.
Yang F; The Department of Medical Genetics, Naval Medical University, Shanghai, China.

Hepatol Commun ; 7(2): e0046, 2023 Feb 01.

Article em En | MEDLINE | ID: mdl-38345896

ABSTRACT

ABSTRACT

NAFLD is a series of liver disorders, and it has become the most prevalent hepatic disease to date. However, there are no approved and effective pharmaceuticals for NAFLD owing to a poor understanding of its pathological mechanisms. While emerging studies have demonstrated that m6A modification is highly associated with NAFLD. In this review, we summarize the general profile of NAFLD and m6A modification, and the role of m6A regulators including erasers, writers, and readers in NAFLD. Finally, we also highlight the clinical significance of m6A in NAFLD.

Assuntos

Hepatopatia Gordurosa não Alcoólica; Humanos; Hepatopatia Gordurosa não Alcoólica/genética; Metilação de RNA

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hepatopatia Gordurosa não Alcoólica Idioma: En Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google