Fetal growth after fresh and frozen embryo transfer and natural conception: A population-based register study.
BJOG
; 131(9): 1229-1237, 2024 Aug.
Article
em En
| MEDLINE
| ID: mdl-38351638
ABSTRACT
OBJECTIVE:
To investigate fetal growth trajectories and risks of small and large for gestational age (SGA and LGA), and macrosomia in pregnancies after fresh and frozen embryo transfer (ET), and natural conception (NC).DESIGN:
Longitudinal population-based cohort study.SETTING:
Swedish national registers. POPULATION A total of 196 008 singleton pregnancies between 2013 and 2017.METHODS:
Of all singleton pregnancies resulting in live births in the Swedish Pregnancy Register, 10 970 fresh ET, 6520 frozen ET, and 178 518 NC pregnancies with ultrasound data were included. A general least squares model was used to examine the effect of fresh or frozen ET on fetal growth while adjusting for confounders. MAIN OUTCOMEMEASURES:
Fetal growth velocity. SGA, LGA and macrosomia.RESULTS:
At 120 days, fetal weights were lower in fresh ET pregnancies compared with NC pregnancies. Thereafter fresh ET as well as FET fetuses had higher fetal weights than NC fetuses, with no differences between themselves until the second trimester. From 210 days, FET fetuses were heavier than fresh ET fetuses, whereas fresh ET fetuses had lower fetal weights than NC fetuses from 245 days. After fresh ET, SGA was more frequent, whereas LGA and macrosomia were less frequent, than after FET.CONCLUSIONS:
This study gives new insights into the differences in fetal growth dynamics between fresh and frozen ET and NC pregnancies. Clinically relevant differences in proportions of SGA, LGA and macrosomia were observed.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Macrossomia Fetal
/
Recém-Nascido Pequeno para a Idade Gestacional
/
Sistema de Registros
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Desenvolvimento Fetal
/
Transferência Embrionária
País/Região como assunto:
Europa
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Suécia