Causal relationship between immune cells and telomere length: mendelian randomization analysis.
BMC Immunol
; 25(1): 19, 2024 Mar 08.
Article
em En
| MEDLINE
| ID: mdl-38459464
ABSTRACT
BACKGROUND:
The causal relationship between immune cells and telomere length remains controversial.METHODS:
Data on the immune cells were obtained from a previous study with 3,757 participants. Data on telomere length were obtained from the OpenGWAS database. Genome-Wide Association Study (GWAS) data were obtained and screened for eligible instrumental variables (IVs) using the TwoSampleMR package and the Phenoscanner database. To investigate the genetic causality between immune cells and telomere length, Mendelian randomization (MR) analysis and Bayesian weighted Mendelian randomization (BWMR) analysis were used.RESULTS:
MR analysis showed that there is indeed a genetic causal relationship between immune cells and telomere length. A total of 16 immune cells were successfully validated. A positive correlation was found between telomere length and immune cells such as CD28 + CD45RA + CD8br %CD8br (OR = 1.002, 95%CI 1.000-1.003). A negative correlation was found between telomere length and immune cells such as Transitional AC (OR = 0.991, 95%CI 0.984-0.997) (P < 0.05). Reverse MR analysis similarly confirmed that telomere length can affect four types of immune cells, including CD25 on IgD + CD24- (OR = 1.291, 95%CI 1.060-1.571), at the genetic level.CONCLUSION:
There is indeed a mutual genetic causality between immune cells and telomere length, which will provide theoretical basis and support for more subsequent clinical studies.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Estudo de Associação Genômica Ampla
/
Análise da Randomização Mendeliana
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China