No evidence for association between rs10191329 severity locus and longitudinal disease severity in 1813 relapse-onset multiple sclerosis patients from the MSBase registry.
Mult Scler
; 30(9): 1216-1220, 2024 Aug.
Article
em En
| MEDLINE
| ID: mdl-38511853
ABSTRACT
BACKGROUND:
The International Multiple Sclerosis Genetics Consortium and MultipleMS Consortium recently reported a genetic variant associated with multiple sclerosis (MS) severity. However, it remains unclear if these variants remain associated with more robust, longitudinal measures of disease severity.METHODS:
We examined the top variant, rs10191329, from Harroud et al.'s study in 1813 relapse-onset MS patients from the MSBase Registry to assess association with longitudinal disease severity.RESULTS:
Our analysis revealed no significant association between rs10191329 genotype and longitudinal binary disease severity (p > 0.05).CONCLUSION:
These findings highlight the complexity of genetic factors mediating long-term MS outcomes and the need for further research.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Índice de Gravidade de Doença
/
Sistema de Registros
/
Esclerose Múltipla Recidivante-Remitente
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Austrália