A Rare Case of Abnormal Diffuse Brain Uptake on an 123I MIBG Scan in a Patient With High-Risk Neuroblastoma.
Clin Nucl Med
; 49(5): 438-441, 2024 May 01.
Article
em En
| MEDLINE
| ID: mdl-38574255
ABSTRACT
ABSTRACT 123I-meta-iodobenzylguanidine (123I-MIBG) is extensively used for initial staging and response evaluation in children with neuroblastoma. Physiological uptake of 123I-MIBG occurs in the salivary glands, liver, adrenal gland, myocardium, bowel, and thyroid gland. 123I-MIBG cannot cross an intact blood-brain barrier. We present the rare case of a 3-year-old boy with neuroblastoma and meningeal metastases who underwent an 123I-MIBG scan for disease restaging that showed abnormal brain uptake. Abnormal MIBG uptake in the brain can occur if there is disruption of the blood-brain barrier either secondary to metastases or after damage to blood-brain barrier.
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Base de dados:
MEDLINE
Assunto principal:
Iodobenzenos
/
Neuroblastoma
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article