Curcumin-loaded mesoporous polydopamine nanoparticles modified by quaternized chitosan against bacterial infection through synergistic effect.
Int J Biol Macromol
; 267(Pt 1): 131372, 2024 May.
Article
em En
| MEDLINE
| ID: mdl-38580024
ABSTRACT
Clinically, open wounds caused by accidental trauma and surgical lesion resection are easily infected by external bacteria, hindering wound healing. Antibacterial photodynamic therapy has become a promising treatment strategy for wound infection. In this study, a novel antibacterial nanocomposite material (QMC NPs) was synthesized by curcumin, quaternized chitosan and mesoporous polydopamine nanoparticles. The results showed that 150 µg/mL QMC NPs had good biocompatibility and exerted excellent antibacterial activity against Staphylococcus aureus and Escherichia coli after blue laser irradiation (450 nm, 1 W/cm2). In vivo, QMC NPs effectively treated bacterial infection and accelerated the healing of infected wounds in mice.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Polímeros
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Staphylococcus aureus
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Curcumina
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Quitosana
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Escherichia coli
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Nanopartículas
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Indóis
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Antibacterianos
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China