Initialization of a Disease Transmission Model.

ABSTRACT

Approaches to the estimation of the full state vector of a larger epidemiological model for the spread of Covid-19 in Sweden at the initial time instant from available data and with a simplified dynamical model are proposed and evaluated. The larger epidemiological model is based on a time-continuous Markov chain and captures the demographic composition of and the transport flows between the counties of Sweden. Its intended use is to predict the outbreak development in temporal and spatial coordinates as well as across the demographic groups. It can also support evaluations and comparisions of prospective intervention strategies in terms of, e.g., lockdown in certain areas or isolation of specific age groups. The simplified model is a discrete time-invariant linear system that has cumulative infectious incidence, infected population, asymptomatic population, exposed population, and infectious pressure as the state variables. Since the system matrix of the model depends on a number of transition rates, structural properties of the model are investigated for suitable parameter ranges. It is concluded that the model becomes unobservable for some parameter values. Two contrasting approaches to the initial state estimation are considered. One is a version of Rauch-Tung-Striebel smoother and another is based on solving a batch nonlinear optimization problem. The benefits and shortcomings of the considered estimation techniques are analyzed and compared.