Osteoporosis: Emerging targets on the classical signaling pathways of bone formation.
Eur J Pharmacol
; 973: 176574, 2024 Jun 15.
Article
em En
| MEDLINE
| ID: mdl-38642670
ABSTRACT
Osteoporosis is a multifaceted skeletal disorder characterized by reduced bone mass and structural deterioration, posing a significant public health challenge, particularly in the elderly population. Treatment strategies for osteoporosis primarily focus on inhibiting bone resorption and promoting bone formation. However, the effectiveness and limitations of current therapeutic approaches underscore the need for innovative methods. This review explores emerging molecular targets within crucial signaling pathways, including wingless/integrated (WNT), bone morphogenetic protein (BMP), hedgehog (HH), and Notch signaling pathway, to understand their roles in osteogenesis regulation. The identification of crosstalk targets between these pathways further enhances our comprehension of the intricate bone metabolism cycle. In summary, unraveling the molecular complexity of osteoporosis provides insights into potential therapeutic targets beyond conventional methods, offering a promising avenue for the development of new anabolic drugs.
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Base de dados:
MEDLINE
Assunto principal:
Osteogênese
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Osteoporose
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Transdução de Sinais
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article