Genomic characterization of human respiratory syncytial virus circulating in Islamabad, Pakistan, during an outbreak in 2022-2023.
Arch Virol
; 169(5): 106, 2024 Apr 22.
Article
em En
| MEDLINE
| ID: mdl-38644429
ABSTRACT
In this study, conducted at the National Institute of Health, Islamabad, during an outbreak of human respiratory syncytial virus (hRSV) from December 2022 to January 2023, the first whole-genome sequences of hRSV isolates from Islamabad, Pakistan, were determined. Out of 10 positive samples, five were sequenced, revealing the presence of two genotypes RSV-A (GA2.3.5, ON1 strain) and RSV-B (GB5.0.5.a, BA-10 strain). A rare non-synonymous substitution (E232G) in G the protein and N276S in the F protein were found in RSV-A. In RSV-B, the unique mutations K191R, Q209R, and I206M were found in the F protein. These mutations could potentially influence vaccine efficacy and viral pathogenicity. This research underscores the importance of genomic surveillance for understanding RSV diversity and guiding public health responses in Pakistan.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Filogenia
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Surtos de Doenças
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Genoma Viral
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Vírus Sincicial Respiratório Humano
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Infecções por Vírus Respiratório Sincicial
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Genótipo
País/Região como assunto:
Asia
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Paquistão