Design, synthesis, and biological application of A-D-A-type boranil fluorescent dyes.
Org Biomol Chem
; 22(18): 3725-3731, 2024 05 08.
Article
em En
| MEDLINE
| ID: mdl-38647088
ABSTRACT
For the first time, three acceptor-donor-acceptor (A-D-A)-type boranil fluorescent dyes, CSU-BF-R (R = H, CH3, and OCH3), featuring phenothiazine as the donor, were designed and synthesized. CSU-BF-R exhibited remarkable photophysical characteristics, including large Stokes shifts (>150 nm), high fluorescence quantum yields (up to 40%), long-wavelength emissions, and strong red solid-state fluorescence. Moreover, these CSU-BF-R fluorescent dyes were demonstrated to function as highly selective and sensitive ratiometric fluorescent probes for detecting hypochlorous acid (HClO). The preliminary biological applications of CSU-BF-OCH3 for sensing intracellular HClO in living cells and zebrafish were demonstrated. Therefore, CSU-BF-R possess the potential to further explore the physiological and pathological functions associated with HClO and provide valuable insights into the design of high-performance A-D-A-type fluorescent dyes.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peixe-Zebra
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Desenho de Fármacos
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Ácido Hipocloroso
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Corantes Fluorescentes
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China