Novel Ultrastructural Insights into the Clear-Cell Carcinoma of the Pancreas: A Case Report.
Int J Mol Sci
; 25(8)2024 Apr 13.
Article
em En
| MEDLINE
| ID: mdl-38673897
ABSTRACT
Pancreatic cancer, most frequently as ductal adenocarcinoma (PDAC), is the third leading cause of cancer death. Clear-cell primary adenocarcinoma of the pancreas (CCCP) is a rare, aggressive, still poorly characterized subtype of PDAC. We report here a case of a 65-year-old male presenting with pancreatic neoplasia. A histochemical examination of the tumor showed large cells with clear and abundant intracytoplasmic vacuoles. The clear-cell foamy appearance was not related to the hyperproduction of mucins. Ultrastructural characterization with transmission electron microscopy revealed the massive presence of mitochondria in the clear-cell cytoplasm. The mitochondria showed disordered cristae and various degrees of loss of structural integrity. Immunohistochemistry staining for NADH dehydrogenase [ubiquinone] 1 alpha subcomplex, 4-like 2 (NDUFA4L2) proved specifically negative for the clear-cell tumor. Our ultrastructural and molecular data indicate that the clear-cell nature in CCCP is linked to the accumulation of disrupted mitochondria. We propose that this may impact on the origin and progression of this PDAC subtype.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Pancreáticas
/
Mitocôndrias
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Itália