Causal analysis of body composition measurements in osteoarthritis knee: a two-sample mendelian randomization study.
BMC Musculoskelet Disord
; 25(1): 341, 2024 Apr 29.
Article
em En
| MEDLINE
| ID: mdl-38684987
ABSTRACT
BACKGROUND:
To analyse the causal associations of different physical measures with osteoarthritis knee (KOA).METHODS:
Exposure factors (weight, body mass index (BMI), body fat percentage, waist circumference, hip circumference, waist-hip ratio (WHR), and basal metabolic rate (BMR)), and outcome factor KOA were analyzed by inverse-variance weighted (IVW) method, along with heterogeneity test, sensitivity and pleiotropy analyses. Meta-analysis was used to combine the effect values of IVW methods in different data sources.RESULTS:
Weight, BMI, body fat percentage, waist circumference, hip circumference and BMR analyses showed causal association with increased KOA risk, while WHR analysis indicated a reduction of the incidence of KOA. P-value for all the results was less than 0.05 and F-value large than 20. All results were negative for heterogeneity tests and sensitivity analyses, and there was pleiotropy in weight and BMR. Meta-analysis results showed that the results of Odds Ratios (95% Confidence Intervals) for Weight (1.43(1.35-1.51)), BMI (1.40(1.10-1.78)), body fat percentage (1.56(1.44-1.68)), waist circumference (1.40(1.10-1.78)), hip circumference (1.37(1.30-1.44)), WHR (0.86(0.71-1.04)) and BMR (1.36(1.27-1.46) were consistent with the ones by Mendelian randomization analyses.CONCLUSIONS:
Body fat percentage may be a better indicator of KOA than BMI. In addition, weight and BMR may have a causal effect in KOA, but WHR does not have a causal relationship. BMI, body fat percentage, waist circumference, and hip circumference has a causal effect on KOA.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Composição Corporal
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Índice de Massa Corporal
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Osteoartrite do Joelho
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Relação Cintura-Quadril
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Análise da Randomização Mendeliana
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China