Disease progression modeling with temporal realignment: An emerging approach to deepen knowledge on chronic diseases.
Pharmacol Ther
; 259: 108655, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38710372
ABSTRACT
The recent development of the first disease-modifying drug for Alzheimer's disease represents a major advancement in dementia treatment. Behind this breakthrough is a quarter century of research efforts to understand the disease not by a particular symptom at a given moment, but by long-term sequential changes in multiple biomarkers. Disease progression modeling with temporal realignment (DPM-TR) is an emerging computational approach proposed with this biomarker-based disease concept. By integrating short-term clinical observations of multiple disease biomarkers in a data-driven manner, DPM-TR provides a way to understand the progression of chronic diseases over decades and predict individual disease stages more accurately. DPM-TR has been developed primarily in the area of neurodegenerative diseases but has recently been extended to non-neurodegenerative diseases, including chronic obstructive pulmonary, autoimmune, and ophthalmologic diseases. This review focuses on opportunities for DPM-TR in clinical practice and drug development and discusses its current status and challenges.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Biomarcadores
/
Progressão da Doença
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Japão