Beyond nanoparticle-based oral drug delivery: transporter-mediated absorption and disease targeting.
Biomater Sci
; 12(12): 3045-3067, 2024 Jun 11.
Article
em En
| MEDLINE
| ID: mdl-38712883
ABSTRACT
Various strategies at the microscale/nanoscale have been developed to improve oral absorption of therapeutics. Among them, gastrointestinal (GI)-transporter/receptor-mediated nanosized drug delivery systems (NDDSs) have drawn attention due to their many benefits, such as improved water solubility, improved chemical/physical stability, improved oral absorption, and improved targetability of their payloads. Their therapeutic potential in disease animal models (e.g., solid tumors, virus-infected lungs, metastasis, diabetes, and so on) has been investigated, and could be expanded to disease targeting after systemic/lymphatic circulation, although the detailed paths and mechanisms of endocytosis, endosomal escape, intracellular trafficking, and exocytosis through the epithelial cell lining in the GI tract are still unclear. Thus, this review summarizes and discusses potential GI transporters/receptors, their absorption and distribution, in vivo studies, and potential sequential targeting (e.g., oral absorption and disease targeting in organs/tissues).
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1
Base de dados:
MEDLINE
Assunto principal:
Nanopartículas
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article