O-GlcNAcylation and immune cell signaling: A review of known and a preview of unknown.
J Biol Chem
; 300(6): 107349, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38718861
ABSTRACT
The dynamic and reversible modification of nuclear and cytoplasmic proteins by O-GlcNAcylation significantly impacts the function and dysfunction of the immune system. O-GlcNAcylation plays crucial roles under both physiological and pathological conditions in the biochemical regulation of all immune cell functions. Three and a half decades of knowledge acquired in this field is merely sufficient to perceive that what we know is just the prelude. This review attempts to mark out the known regulatory roles of O-GlcNAcylation in key signal transduction pathways and specific protein functions in the immune system and adumbrate ensuing questions toward the unknown functions.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Acetilglucosamina
/
Transdução de Sinais
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article