Ribonuclease inhibitor and angiogenin system regulates cell type-specific global translation.
Sci Adv
; 10(22): eadl0320, 2024 May 31.
Article
em En
| MEDLINE
| ID: mdl-38820160
ABSTRACT
Translation of mRNAs is a fundamental process that occurs in all cell types of multicellular organisms. Conventionally, it has been considered a default step in gene expression, lacking specific regulation. However, recent studies have documented that certain mRNAs exhibit cell type-specific translation. Despite this, it remains unclear whether global translation is controlled in a cell type-specific manner. By using human cell lines and mouse models, we found that deletion of the ribosome-associated protein ribonuclease inhibitor 1 (RNH1) decreases global translation selectively in hematopoietic-origin cells but not in the non-hematopoietic-origin cells. RNH1-mediated cell type-specific translation is mechanistically linked to angiogenin-induced ribosomal biogenesis. Collectively, this study unravels the existence of cell type-specific global translation regulators and highlights the complex translation regulation in vertebrates.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ribonuclease Pancreático
/
Ribossomos
/
Biossíntese de Proteínas
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Suíça