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Rationally Minimizing Natural Product Libraries Using Mass Spectrometry.
Ness, Monica; Peramuna, Thilini; Wendt, Karen L; Collins, Jennifer E; King, Jarrod B; Paes, Raphaella; Santos, Natalia Mojica; Okeke, Crystal; Miller, Cameron R; Chakrabarti, Debopam; Cichewicz, Robert H; McCall, Laura-Isobel.
Afiliação
  • Ness M; Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, United States.
  • Peramuna T; Department of Chemistry and Biochemistry, San Diego State University, San Diego, California, 92182, United States.
  • Wendt KL; Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, United States.
  • Collins JE; Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, United States.
  • King JB; Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida, 32826, United States.
  • Paes R; Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, United States.
  • Santos NM; Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida, 32826, United States.
  • Okeke C; Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida, 32826, United States.
  • Miller CR; Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, United States.
  • Chakrabarti D; Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, United States.
  • Cichewicz RH; Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida, 32826, United States.
  • McCall LI; Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, United States.
bioRxiv ; 2024 May 26.
Article em En | MEDLINE | ID: mdl-38826280
ABSTRACT
Natural product libraries are crucial to drug development, but large libraries drastically increase the time and cost during initial high throughput screens. Here, we developed a method that leverages liquid chromatography-tandem mass spectrometry spectral similarity to dramatically reduce library size, with minimal bioactive loss. This method offers a broadly applicable strategy for accelerated drug discovery with cost reductions, which enable implementation in resource-limited settings.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos