Does cardiorespiratory fitness mediate or moderate the association between mid-life physical activity frequency and cognitive function? findings from the 1958 British birth cohort study.
PLoS One
; 19(6): e0295092, 2024.
Article
em En
| MEDLINE
| ID: mdl-38848437
ABSTRACT
BACKGROUND:
Physical activity (PA) is associated with a lower risk of cognitive decline and all-cause dementia in later life. Pathways underpinning this association are unclear but may involve either mediation and/or moderation by cardiorespiratory fitness (CRF).METHODS:
Data on PA frequency (exposure) at 42y, non-exercise testing CRF (NETCRF, mediator/moderator) at 45y and overall cognitive function (outcome) at 50y were obtained from 9,385 participants (50.8% female) in the 1958 British birth cohort study. We used a four-way decomposition approach to examine the relative contributions of mediation and moderation by NETCRF on the association between PA frequency at 42y and overall cognitive function at 50y.RESULTS:
In males, the estimated overall effect of 42y PA ≥once per week (vs.CONCLUSION:
We present the first evidence from a four-way decomposition analysis of the potential contribution that CRF plays in the relationship between mid-life PA frequency and subsequent cognitive function. Our lack of evidence in support of CRF mediating or moderating the PA frequency-cognitive function association suggests that other pathways underpin this association.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Exercício Físico
/
Cognição
/
Aptidão Cardiorrespiratória
País/Região como assunto:
Europa
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Reino Unido