Your browser doesn't support javascript.
loading
Probing the neurocardiac circuit in trauma and posttraumatic stress.
Seligowski, Antonia V; Harnett, Nathaniel G; Ellis, Robyn A; Grasser, Lana R; Hanif, Mubeena; Wiltshire, Charis; Ely, Timothy D; Lebois, Lauren A M; van Rooij, Sanne J H; House, Stacey L; Beaudoin, Francesca L; An, Xinming; Neylan, Thomas C; Clifford, Gari D; Linnstaedt, Sarah D; Germine, Laura T; Bollen, Kenneth A; Rauch, Scott L; Haran, John P; Storrow, Alan B; Lewandowski, Christopher; Musey, Paul I; Hendry, Phyllis L; Sheikh, Sophia; Jones, Christopher W; Punches, Brittany E; Swor, Robert A; Hudak, Lauren A; Pascual, Jose L; Seamon, Mark J; Harris, Erica; Pearson, Claire; Peak, David A; Merchant, Roland C; Domeier, Robert M; Rathlev, Niels K; O'Neil, Brian J; Sergot, Paulina; Sanchez, Leon D; Bruce, Steven E; Harte, Steven E; Koenen, Karestan C; Kessler, Ronald C; McLean, Samuel A; Ressler, Kerry J; Stevens, Jennifer S; Jovanovic, Tanja.
Afiliação
  • Seligowski AV; Massachusetts General Hospital, Boston, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA. Electronic address: aseligowski@mgh.harvard.edu.
  • Harnett NG; Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Division of Depression and Anxiety, McLean Hospital, Belmont, MA, USA.
  • Ellis RA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Division of Depression and Anxiety, McLean Hospital, Belmont, MA, USA.
  • Grasser LR; Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI, USA.
  • Hanif M; Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI, USA.
  • Wiltshire C; Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI, USA.
  • Ely TD; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
  • Lebois LAM; Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Division of Depression and Anxiety, McLean Hospital, Belmont, MA, USA.
  • van Rooij SJH; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
  • House SL; Department of Emergency Medicine, Washington University School of Medicine, St. Louis, MO, USA.
  • Beaudoin FL; Department of Epidemiology, Brown University, Providence, RI, USA; Department of Emergency Medicine, Brown University, Providence, RI, USA.
  • An X; Institute for Trauma Recovery, Department of Anesthesiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Neylan TC; Departments of Psychiatry and Neurology, University of California San Francisco, San Francisco, CA, USA.
  • Clifford GD; Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA, USA; Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
  • Linnstaedt SD; Institute for Trauma Recovery, Department of Anesthesiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Germine LT; Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Institute for Technology in Psychiatry, McLean Hospital, Belmont, MA, USA; The Many Brains Project, Belmont, MA, USA.
  • Bollen KA; Department of Psychology and Neuroscience & Department of Sociology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Rauch SL; Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Institute for Technology in Psychiatry, McLean Hospital, Belmont, MA, USA; Department of Psychiatry, McLean Hospital, Belmont, MA, USA.
  • Haran JP; Department of Emergency Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
  • Storrow AB; Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Lewandowski C; Department of Emergency Medicine, Henry Ford Health System, Detroit, MI, USA.
  • Musey PI; Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
  • Hendry PL; Department of Emergency Medicine, University of Florida College of Medicine -Jacksonville, Jacksonville, FL, USA.
  • Sheikh S; Department of Emergency Medicine, University of Florida College of Medicine -Jacksonville, Jacksonville, FL, USA.
  • Jones CW; Department of Emergency Medicine, Cooper Medical School of Rowan University, Camden, NJ, USA.
  • Punches BE; Department of Emergency Medicine, Ohio State University College of Medicine, Columbus, OH, USA; Ohio State University College of Nursing, Columbus, OH, USA.
  • Swor RA; Department of Emergency Medicine, Oakland University William Beaumont School of Medicine, Rochester, MI, USA.
  • Hudak LA; Department of Emergency Medicine, Emory University School of Medicine, Atlanta, GA, USA.
  • Pascual JL; Department of Surgery, Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, USA; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Seamon MJ; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Surgery, Division of Traumatology, Surgical Critical Care and Emergency Surgery, University of Pennsylvania, Philadelphia, PA, USA.
  • Harris E; Department of Emergency Medicine, Einstein Medical Center, Philadelphia, PA, USA.
  • Pearson C; Department of Emergency Medicine, Wayne State University, Ascension St. John Hospital, Detroit, MI, USA.
  • Peak DA; Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Merchant RC; Department of Emergency Medicine, Brigham and Women's Hospital, Boston, MA, USA.
  • Domeier RM; Department of Emergency Medicine, Trinity Health-Ann Arbor, Ypsilanti, MI, USA.
  • Rathlev NK; Department of Emergency Medicine, University of Massachusetts Medical School-Baystate, Springfield, MA, USA.
  • O'Neil BJ; Department of Emergency Medicine, Wayne State University, Detroit Receiving Hospital, Detroit, MI, USA.
  • Sergot P; Department of Emergency Medicine, McGovern Medical School at UTHealth, Houston, TX, USA.
  • Sanchez LD; Department of Emergency Medicine, Brigham and Women's Hospital, Boston, MA, USA; Department of Emergency Medicine, Harvard Medical School, Boston, MA, USA.
  • Bruce SE; Department of Psychological Sciences, University of Missouri - St. Louis, St. Louis, MO, USA.
  • Harte SE; Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, USA; Department of Internal Medicine-Rheumatology, University of Michigan Medical School, Ann Arbor, MI, USA.
  • Koenen KC; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.
  • Kessler RC; Department of Health Care Policy, Harvard Medical School, Boston, MA, USA.
  • McLean SA; Department of Emergency Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Institute for Trauma Recovery, Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Ressler KJ; Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Division of Depression and Anxiety, McLean Hospital, Belmont, MA, USA.
  • Stevens JS; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
  • Jovanovic T; Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI, USA.
J Psychiatr Res ; 176: 173-181, 2024 Aug.
Article em En | MEDLINE | ID: mdl-38875773
ABSTRACT
The neurocardiac circuit is integral to physiological regulation of threat and trauma-related responses. However, few direct investigations of brain-behavior associations with replicable physiological markers of PTSD have been conducted. The current study probed the neurocardiac circuit by examining associations among its core regions in the brain (e.g., insula, hypothalamus) and the periphery (heart rate [HR], high frequency heart rate variability [HF-HRV], and blood pressure [BP]). We sought to characterize these associations and to determine whether there were differences by PTSD status. Participants were N = 315 (64.1 % female) trauma-exposed adults enrolled from emergency departments as part of the prospective AURORA study. Participants completed a deep phenotyping session (e.g., fear conditioning, magnetic resonance imaging) two weeks after emergency department admission. Voxelwise analyses revealed several significant interactions between PTSD severity 8-weeks posttrauma and psychophysiological recordings on hypothalamic connectivity to the prefrontal cortex (PFC), insula, superior temporal sulcus, and temporoparietaloccipital junction. Among those with PTSD, diastolic BP was directly correlated with right insula-hypothalamic connectivity, whereas the reverse was found for those without PTSD. PTSD status moderated the association between systolic BP, HR, and HF-HRV and hypothalamic connectivity in the same direction. While preliminary, our findings may suggest that individuals with higher PTSD severity exhibit compensatory neural mechanisms to down-regulate autonomic imbalance. Additional study is warranted to determine how underlying mechanisms (e.g., inflammation) may disrupt the neurocardiac circuit and increase cardiometabolic disease risk in PTSD.
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtornos de Estresse Pós-Traumáticos / Pressão Sanguínea / Imageamento por Ressonância Magnética / Frequência Cardíaca Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtornos de Estresse Pós-Traumáticos / Pressão Sanguínea / Imageamento por Ressonância Magnética / Frequência Cardíaca Idioma: En Ano de publicação: 2024 Tipo de documento: Article