Synthesis, antibacterial and antibiofilm activity of new 1,2,3,5-tetrazine derivatives from coupling reactions of diazonium salt of 2-amino-6-nitrobenzothiazole with diverse substituted 2-aminobenzothiazole derivatives.
Acta Chim Slov
; 71(2): 353-362, 2024 Jun 10.
Article
em En
| MEDLINE
| ID: mdl-38919107
ABSTRACT
The coupling reaction of diazonium ion of 2-amino-6-nitrobenzothiazole at 0-5 °C with distinctly substituted 2-aminobenzothiazole derivatives produced new 1,2,3,5-tetrazine derivatives. It was found that diazotized 2-amino-6-nitrobenzo[d]thiazol reacts with the ring nitrogen atom of varyingly substituted 2-aminobenzothiazole derivatives to yield tetrazine nucleus. The benzene ring of benzothiazole bearing electron donor group and annelated to the tetrazine was further substituted in situ by other 6-nitrobenzo[d]thiazol-2-yl) diazinyl to yield the final product. The structure of the prepared compounds was elucidated using their physical, elemental, and spectroscopic data. The synthesized compounds were tested for their antimicrobial and antibiofilm activities against Staphylococcus aureus and Escherichia coli bacteria. Two of the synthesis tetrazine derivatives exhibited interesting antibiofilm potential.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Staphylococcus aureus
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Testes de Sensibilidade Microbiana
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Biofilmes
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Escherichia coli
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Benzotiazóis
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Antibacterianos
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Camarões