Age of type 2 diabetes onset as a risk factor for dementia: A 13-year retrospective cohort study.
Diabetes Res Clin Pract
; 213: 111760, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38925296
ABSTRACT
AIMS:
To examine whether age at type 2 diabetes onset is an independent predictor of dementia risk.METHODS:
Retrospective cohort drawn from healthcare administrative records of all inhabitants within Romagna's catchment area, Italy, with an estimated onset of type 2 diabetes in 2008-2017 and aged ≥ 55, with follow-up until 2020. Time to dementia or censoring was estimated with the Kaplan-Meier method, using diabetes onset as the time origin. Age groups were compared with the log-rank test. Multivariable competing-risks analysis was used to assess predictors of dementia.RESULTS:
In patients aged ≥ 75 years, dementia-free survival (DFS) declined to below 90 % within five years and linearly decreased to 68.8 % until the end of follow-up. In contrast, DFS for those aged 55-64 years showed a marginal decrease, reaching 97.4 % after 13 years. Competing-risks regression showed that individuals aged ≥ 75 and 65-74 had a significantly higher risk of dementia compared to those aged 55-64 years. Having more comorbidities at diabetes onset and initial treatment with ≥ 2 antidiabetics were clinical predictors.CONCLUSIONS:
Later age at onset of diabetes is strongly associated with dementia. A better understanding of the diabetes-dementia relationship is needed to inform strategies for promoting specific healthcare pathways.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Idade de Início
/
Demência
/
Diabetes Mellitus Tipo 2
País/Região como assunto:
Europa
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Itália