Lysergic acid diethylamide induces behavioral changes in Caenorhabditis elegans.
Neurosci Lett
; 837: 137903, 2024 Aug 10.
Article
em En
| MEDLINE
| ID: mdl-39025433
ABSTRACT
Lysergic acid diethylamide (LSD) is a synthetic psychedelic compound with potential therapeutic value for psychiatric disorders. This study aims to establish Caenorhabditis elegans as an in vivo model for examining LSD's effects on locomotor behavior. Our results demonstrate that LSD is absorbed by C. elegans and that the acute treatment reduces animal speed, similar to the role of endogenous serotonin. This response is mediated in part by the serotonergic receptors SER-1 and SER-4. Our findings highlight the potential of this nematode as a new experimental model in psychedelic research.
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Base de dados:
MEDLINE
Assunto principal:
Caenorhabditis elegans
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Alucinógenos
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Dietilamida do Ácido Lisérgico
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Brasil