Novel metabolic biomarkers for the diagnosis of acute ischemic stroke.

ABSTRACT

Aim: To identify novel metabolic biomarkers for patients with acute ischemic stroke (AIS).Methods: The metabolites in the sera of 63 patients with AIS aged 45∼77 years and 60 healthy individuals were analyzed by liquid chromatography (LC)-mass spectrometry (MS)/MS. The efficiency of significantly altered metabolites as biomarkers of AIS was evaluated by ROC curve analysis.Results: Different metabolic profiles were revealed in AIS patients' sera compared with healthy persons. Twelve significantly altered metabolites had an area under the curve (AUC) value >0.80, demonstrating their potential as a biomarker of AIS. Among them, six metabolites are firstly reported to distinguish between AIS patients and healthy individuals.Conclusion: These 12 metabolites can be further researched as potential diagnostic biomarkers of AIS.

In this study, the serum metabolome of patients with AIS aged 45­77 years were analyzed and the potential biomarkers for AIS diagnosis were identified. Twelve serum compounds were found to be significantly altered and have the ability to distinguish patients with AIS and healthy individuals effectively. Among them, six metabolites were firstly reported to have the potential as biomarkers for AIS diagnosis. These results will contribute to biomarker explorations from blood metabolites to predict AIS in patients from different age groups.