Activation of complement by radiographic contrast media: generation of chemotactic and anaphylatoxin activities.
Int Arch Allergy Appl Immunol
; 56(6): 543-50, 1978.
Article
em En
| MEDLINE
| ID: mdl-415989
ABSTRACT
Iodinated radiographic contrast media such as methylglucamine diatrizoate and sodium ioglycamate activate serum complement in vitro. This was shown by a dose-, time-, and temperature-dependent decrease of total hemolytic complement activity in normal human serum, consumption of C4 and C6 activity, conversion of C3 to C3b, and generation of C5-derived chemotactic and smooth muscle contracting activity. Complement activation was achieved even in sera depleted of immunoglobulin and properdin, which may indicate that contrast media induce complement activation by mechanisms different from the classical or alternative pathway.
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Base de dados:
MEDLINE
Assunto principal:
Biossíntese Peptídica
/
Proteínas do Sistema Complemento
/
Quimiotaxia
/
Anafilatoxinas
/
Meios de Contraste
Idioma:
En
Ano de publicação:
1978
Tipo de documento:
Article