High-performance liquid chromatographic separation of the enantiomers of anti-inflammatory 2-arylpropionates: suitability of the method for in vitro metabolic studies.
J Chromatogr
; 299(2): 397-403, 1984 Sep 21.
Article
em En
| MEDLINE
| ID: mdl-6501476
ABSTRACT
The enantiomers of 2-phenylpropionic acid, 2-(2-naphthyl)propionic acid, 2-(4-biphenyl)propionic acid and six anti-inflammatory congeners were separated by high-performance liquid chromatography via their diastereoisomeric derivatives with (S)-(-)-1-phenylethylamine. In agreement with a general rule, the diastereoisomers derived from the (R)-acids are less polar and elute first. Structural factors influencing the resolution are discussed. Good calibrations were obtained for R/S ratios and total (R + S) concentrations of flurbiprofen and naproxen added to inactivated rat liver preparations. The method is suitable for in vitro metabolic studies of chiral 2-arylpropionates.
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Base de dados:
MEDLINE
Assunto principal:
Propionatos
/
Anti-Inflamatórios
Idioma:
En
Ano de publicação:
1984
Tipo de documento:
Article