Development and preliminary pharmacologic evaluation of a zwitterionic oral cholecystographic agent.
Invest Radiol
; 16(6): 513-6, 1981.
Article
em En
| MEDLINE
| ID: mdl-7319759
ABSTRACT
A new zwitterionic iodinated molecule, 2-[3-(N-ethyl-2-hydroxyethyl) amino-acetamido-2, 4, 6-triiodobenzyl]-butyric acid (RCK-136) was synthesized, and its potential as an oral cholecystopaque was tested. In rats, 15 minutes following intravenous injection, RCK-136 reached maximum biliary concentration; 84% of the dose was excreted into bile. Biliary excretion of RCK-136 elicited a strong choleresis (44 ml of bile flow per mmol compound). Intravenous LD50 in rats averaged 390 mgI/kg. ED50 in rats, intradiencephalic, averaged 1.98 mgI/kg. The average densities of cholecystograms produced in three dogs with iosumetic acid and/or RCK-136 were comparable.
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Base de dados:
MEDLINE
Assunto principal:
Colecistografia
/
Meios de Contraste
/
Iodobenzenos
Idioma:
En
Ano de publicação:
1981
Tipo de documento:
Article