Therapeutic effects of ML-236B in primary hypercholesterolemia.
Atherosclerosis
; 35(3): 259-66, 1980 Mar.
Article
em En
| MEDLINE
| ID: mdl-7362699
ABSTRACT
ML-236B, a competitive inhibitor of 3-hydroxy-3-methylglutaryl CoA reductase, was administered to 11 patients with primary hypercholesterolemia. After 4--8 weeks of drug treatment at doses of 50--150 mg/day, serum cholesterol levels were reduced by 11--37% (27% on average) in cases of heterozygous familial hypercholesterolemia and combined hyperlipidemia. A marked reduction in tuberous xanthomas was noticed in a homozygous case of familial hypercholesterolemia, but here the drug was less effective in reducing the serum cholesterol level and a higher dose was required for treatment. Softening of Achilles tendon xantomas was observed in a case of combined hyperlipidemia.
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Base de dados:
MEDLINE
Assunto principal:
Lovastatina
/
Hipercolesterolemia
/
Anticolesterolemiantes
/
Naftalenos
Idioma:
En
Ano de publicação:
1980
Tipo de documento:
Article